{"id":5379,"date":"2022-03-14T12:37:16","date_gmt":"2022-03-14T12:37:16","guid":{"rendered":"https:\/\/drmirkin.com\/?p=5379"},"modified":"2022-03-14T23:14:42","modified_gmt":"2022-03-14T23:14:42","slug":"muhammed-ali-parkinsons-breakthroughs-are-coming","status":"publish","type":"post","link":"http:\/\/drmirkin.com\/?p=5379","title":{"rendered":"Muhammed Ali: Parkinson&#8217;s Breakthroughs are Coming"},"content":{"rendered":"<p>Muhammed Ali was honored by presidents and kings as the most famous athlete in the world. He was an Olympic gold medalist and three-time heavyweight world champion. His ancestors were slaves in the pre-Civil War South with some Irish and English in their heritage. His mother, Odessa O&#8217;Grady Clay, was a domestic and his father was a sign painter. As a child, he suffered all of the indignities of segregation in the South and he told reporters, &#8220;I started boxing because I thought this was the fastest way for a black person to make it in this country.&#8221;<\/p>\n<p>His behavior in and out of the ring was often outrageous, but he ended up being recognized as one of the most courageous people of the 20th century. He stood up for his convictions and became a role model for the black pride movement.<br \/>\n\u2022 He converted to Islam and joined the Nation of Islam, a radical group that many people saw as a threat to America&#8217;s social order.<br \/>\n\u2022 In 1964, he got rid of his \u201cslave name&#8221;, Cassius Clay, and became Muhammed Ali, a &#8220;free name&#8221; that reflected his new religion.<br \/>\n\u2022 In 1966, he gave up his world boxing championship and millions of dollars when he refused to be drafted, citing his religious beliefs and opposition to the Vietnam War.<br \/>\n\u2022 He rejected integration at the height of the civil rights movement,<br \/>\n\u2022 He was one of the strongest voices against the prevailing racial, religious and political beliefs. However, while he had joined an organization that emphasized strong family values, he had five marriages and two children outside of marriage.<\/p>\n<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/jkhpZoPOfZI\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><br \/>\n<strong>Early Signs of Health Problems<\/strong><br \/>\nIn 1978 at age 36, as one of the greatest fighters ever, he lost a 15 round decision to Leon Spinks who was smaller and 12 years younger. Seven months later, he won the rematch and regained the heavyweight championship for the third time. By then, something was wrong. He was not as quick or coordinated as he had always been, but did not know why. He told reporters: &#8220;I&#8217;d be a fool to fight again.&#8221;<\/p>\n<p>He did fight two more bouts and lost them both. In 1981, he stopped fighting for good because his hands shook, he walked with a shuffle, and he had slurred speech, even though he did not have the classic boxer&#8217;s broken nose and cauliflower ears. It wasn&#8217;t until 1984, at age 42, that doctors finally diagnosed him as having Parkinson&#8217;s disease that took away his incredible athleticism and even his ability to speak clearly. Doctors told him that Parkinson&#8217;s disease was the result of his long boxing career, but I think that is unlikely.<\/p>\n<p>He lit the flame at the opening ceremony of the 1996 Summer Olympics in Atlanta with hands shaking so badly that he almost dropped the torch he was carrying. In 2006, an entertainment company, CKX Inc., paid him and his wife $50 million for the commercial rights to his name. On June 3, 2016, he died of a respiratory ailment common to people who suffer from Parkinson&#8217;s disease.<\/p>\n<p><strong>Not Chronic Traumatic Encephalopathy (CTE)<\/strong><br \/>\nMany of Ali&#8217;s obituaries reported that his Parkinson&#8217;s disease was a form of Chronic Traumatic Encephalopathy (CTE), a progressive degenerative disease found in people who have been hit in the head in sports such as boxing, football, ice hockey, wrestling and so forth, or from domestic violence. There is a link between head trauma and Parkinson&#8217;s disease (<em>Occup Environ Med<\/em>, Dec, 2013;70(12):839-44), but if it is the cause, it is rare because the vast majority of people with Parkinson&#8217;s disease do not have a history of head trauma and Parkinson&#8217;s disease has its own progressive list of symptoms that are much different from those of CTE.<br \/>\n<iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/G9JRWAkUn7E\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><br \/>\n<strong>Early Parkinson&#8217;s Symptoms<\/strong><br \/>\nPeople with Parkinson&#8217; disease have a lengthy list of progressive symptoms long before they are diagnosed. They often start with loss of smell, then constipation, dizziness and urinary problems, then a type of sleep disorder called REM-sleep behavior disorder in which they physically enact their dreams. They usually have breathing problems.<\/p>\n<p>Their progression of symptoms differs from head trauma (CTE) victims. Parkinson&#8217;s patients typically have:<br \/>\n\u2022 inability to swallow, drooling, tremor, muscle rigidity and slow movement<br \/>\n\u2022 symptoms usually beginning on one side of the body and always worse on that side<br \/>\n\u2022 shaking that starts in the fingers and moves up the arms, slowed movement that can eventually prevent a person from doing simple tasks, dragging feet, short steps, difficulty getting out of a chair, rigid and stiff muscles, bent over posture, loss of balance<br \/>\n\u2022 inability to blink or smile or to move arms while walking<br \/>\n\u2022 speech changes such as soft voice, monotones, slurring or delayed speech<br \/>\n\u2022 inability to write legibly<br \/>\n\u2022 sleep disorders such as frequent waking during the night and falling asleep during the day<br \/>\n\u2022 loss of sexual function<br \/>\n\u2022 great fatigue<br \/>\n\u2022 pain anywhere in the body .<\/p>\n<p><strong>Breakthroughs in Parkinson&#8217;s Disease<\/strong><br \/>\nParkinson&#8217;s disease is caused by damage to the substantia nigra part of the brain that makes dopamine, a chemical that sends messages from one nerve to another (<em>npj Parkinson&#8217;s Disease,<\/em>\u00a0March 26, 2018;4(9)). Now we have to explain how a person loses dopamine to develop Parkinson&#8217;s disease. In 1991, Heiko Braak, a neurologist at Ulm University in Germany made the brilliant proposal that Parkinson\u2019s disease starts outside the body. He explained how Parkinson&#8217;s disease symptoms progress. First damage is to the involuntary nerves that cover the eye, stomach, salivary glands, and intestines; then to the motor nerves that move your muscles; and finally to the nerves that help you to think and reason.<\/p>\n<p>The toxic protein behind Parkinson&#8217;s disease, called alpha-synuclein, can affect all parts of the nervous system inside and outside of the brain (<em>Trends in Neuroscience<\/em>, Jan 1, 2017;40(1):4-14). He proposed that something is:<br \/>\n\u2022 inhaled from the air to damage the nerves that allow you to smell (loss of smell),<br \/>\n\u2022 then swallowed to be absorbed into the gut (belching and terrible constipation)<br \/>\n\u2022 there it causes alpha-synuclein to be made in the nerves in the stomach and<br \/>\n\u2022 travel up the vagus nerve that runs from the stomach<br \/>\n\u2022 to the brain stem from the medulla to the pons (tremor, rigidity and slow movements)<br \/>\n\u2022 to the midbrain<br \/>\n\u2022 to accumulate in the substantia nigra and the brain cortex (loss of cells that make dopamine)<br \/>\n<iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/jvVbgnCiyo0\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><br \/>\n<strong>Proof from an Outdated Procedure<\/strong><br \/>\nMany years ago, doctors incorrectly treated stomach ulcers by cutting the vagus nerve that increases acid secretion in the stomach. Recently, researchers reviewed medical records of patients who had undergone this vagus nerve cutting called truncal vagotomy. They found that people who had a truncal vagotomy were protected significantly against the development of Parkinson&#8217;s disease, compared to those who had another procedure called superselective vagotomy. This confirms that Heiko Braak&#8217;s theory is most likely correct. Cutting the vagus nerve blocks the pathway that the misfolded proteins (called prions) travel from the stomach up to the brain to destroy the nerve cells that make dopamine. Lack of dopamine causes Parkinson\u2019s disease.<\/p>\n<p>\u2022 We do not know what triggers Parkinson&#8217;s disease.<br \/>\n\u2022 Most likely it is caused by something that is eaten or inhaled, possibly a prion.<br \/>\n\u2022 Head trauma may be an unusual or contributing cause.<br \/>\n\u2022 The drugs that are currently used to treat Parkinson&#8217;s disease raise levels of dopamine, a chemical that sends messages from one nerve to another. These drugs lose their effect over time.<br \/>\n\u2022 In the near future, Parkinson&#8217;s disease is likely to be diagnosed by a biopsy of the intestines and nose to look for the pathological form of the protein alpha-synuclein.<\/p>\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Muhammad_Ali\">Muhammed Ali<\/a><br \/>\nJanuary 17, 1942 \u2013 June 3, 2016.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Muhammed Ali was honored by presidents and kings as the most famous athlete in the world. He was an Olympic gold medalist and three-time heavyweight world champion. His ancestors were slaves in the pre-Civil War South with some Irish and English in their heritage. His mother, Odessa O&#8217;Grady Clay, was a domestic and his father was a sign painter. As a child, he suffered all of the indignities of segregation in the South and he told reporters, &#8220;I started boxing because I thought this was the fastest way for a black person to make it in this country.&#8221;<\/p>\n","protected":false},"author":1,"featured_media":7602,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[18],"tags":[1101,665,664,377],"class_list":["post-5379","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-histories-and-mysteries","tag-alpha-synuclein","tag-chronic-traumatic-encephalopathy","tag-cte","tag-dopamine"],"_links":{"self":[{"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/posts\/5379","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/drmirkin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5379"}],"version-history":[{"count":0,"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/posts\/5379\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/media\/7602"}],"wp:attachment":[{"href":"http:\/\/drmirkin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5379"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/drmirkin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5379"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/drmirkin.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5379"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}