{"id":5870,"date":"2022-08-05T13:24:26","date_gmt":"2022-08-05T13:24:26","guid":{"rendered":"https:\/\/drmirkin.com\/?p=5870"},"modified":"2022-08-05T13:24:27","modified_gmt":"2022-08-05T13:24:27","slug":"gut-bacteria-associated-with-colon-cancer","status":"publish","type":"post","link":"http:\/\/drmirkin.com\/?p=5870","title":{"rendered":"Gut Bacteria Associated with Colon Cancer"},"content":{"rendered":"<p>A study from Harvard Medical School found that a typical Western diet increases growth of specific bacteria in the gut called \u201cpolyketide synthase (pks+) E. Coli\u201d that produce a chemical called colibactin, which causes DNA mutations that can turn normal colon cells into cancer cells (<em>Gastroenterology<\/em>, June 23, 2022). Other studies have found the same association (<em>Cancer Sci<\/em>, Jan 2022;113(1):277-286; <em>Gastroenterology<\/em>, 2017 Dec;153(6):1517-1530). Many studies have previously shown that the Western Diet causes <a href=\"https:\/\/drmirkin.com\/health\/inflammation-can-help-or-harm.html\">inflammation<\/a>, that is associated with increased risk for colon cancer (<em>Gastroenterology<\/em>, Jun 2017;152(8):1944-1953). A typical Western diet is high in <a href=\"https:\/\/drmirkin.com\/nutrition\/antiinflammatory-and-proinflammatory-foods.html\">pro-inflammatory foods<\/a> such as red meat, processed meats, sugar-added foods, refined grains and fried foods; and low in <a href=\"https:\/\/drmirkin.com\/nutrition\/antiinflammatory-and-proinflammatory-foods.html\">anti-inflammatory foods<\/a> such as vegetables, beans and unground whole grains.<\/p>\n<p>The authors of the Harvard study used data from 134,775 adults participating in the Health Professionals Follow-up Study and the Nurses&#8217; Health Study. They found the bacteria (polyketide synthase E. Coli) in 111 colon tumors, and the more components of the Western diet a person ate, the higher the levels of these bacteria in the cancer. The authors state: \u201cOur findings provide evidence supporting the role of the gut microbiota in mediating the pathogenic link between diet and colorectal cancer.&#8221;<\/p>\n<p><strong>My Recommendations<\/strong><br \/>\nThe evidence gets stronger every day that several cancers, such as those of the breast, prostate or colon, are associated with an inflammatory lifestyle and diet that includes:<br \/>\n\u2022 sugar-added foods and refined carbohydrates (<em>BMJ<\/em>, February 14, 2018;360:k322)<br \/>\n\u2022 mammal meat and processed meats (<em>Oncol Rev<\/em>, Feb 10, 2015;9(1))<br \/>\n\u2022 fried foods (<em>Prostate<\/em>, Jun 2013;73(9):960\u2013969)<br \/>\n<a href=\"https:\/\/drmirkin.com\/nutrition\/antiinflammatory-and-proinflammatory-foods.html\">Anti-inflmmatory Foods<\/a> that help to protect you from cancer include fruits, vegetables, whole grains, beans, and nuts (<em>BMJ<\/em>, Mar 5, 2020;368:m511. PMC7190379).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study from Harvard Medical School found that a typical Western diet increases growth of specific bacteria in the gut called \u201cpolyketide synthase (pks+) E. Coli\u201d that produce a chemical called colibactin, which causes DNA mutations that can turn normal colon cells into cancer cells.<\/p>\n","protected":false},"author":1,"featured_media":1023,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[25],"tags":[276,995,93,1149],"class_list":["post-5870","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-morehealth","tag-colon-cancer","tag-e-coli","tag-gut-bacteria","tag-polyketide"],"_links":{"self":[{"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/posts\/5870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/drmirkin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5870"}],"version-history":[{"count":0,"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/posts\/5870\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/drmirkin.com\/index.php?rest_route=\/wp\/v2\/media\/1023"}],"wp:attachment":[{"href":"http:\/\/drmirkin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/drmirkin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5870"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/drmirkin.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}