Women and men who exercise regularly have larger and stronger hearts, and greater endurance and strength, than those who do not exercise regularly (J of Physiology, 2022 Apr;600(8):1969-1989). Their muscles are stronger and more coordinated (J of Physiology (IF5.182), April 29, 2020). We can all expect to become weaker as we age, but you can markedly delay this inevitable loss of muscle strength by having a regular exercise program and following the same anti-inflammatory lifestyle rules that are recommended to help prevent heart attacks (Ageing Res Rev, 2021 Jul;68:101344; Front Genet, July 2, 2021), cancers (JAMA Internal Medicine, 2016; 176(6):816-825), and many other diseases.

Older people who suffer from severe loss of muscles (called sarcopenia) are far more likely to have high levels of the markers of inflammation, measured with blood tests such as CRP, SED rate and adiponectin (Aging Clin and Experiment Res, August 2017;29(4):745-752). Sarcopenia is found in other conditions associated with chronic inflammation, including:
• having excess body fat (J Gerontology A Biol Sci Med Sci, 2011;66:888-895; Curr Gerontol Geriatr Res, 2012;2012:216185)
• eating a pro-inflammatory diet that raises blood sugar levels (J Gerontology A Biol Sci Med Sci, Jan 2012;67A(1):74-81)
• being diabetic (Med J Aust, 2016;205(7):329-333)
• having low vitamin D levels (Molecular Aspects of Medicine, Dec 2008;29(6):407-4140)
• not exercising (Euro Soc for Clin Invest J, 2017;47:600-611)
• having any chronic disease

What is Inflammation?
Your immune system helps to heal wounds and to protect you from infections, but it is supposed to dampen down after an infection has passed or an injury has healed. If your immune system stays overactive, it can use the same cells and chemicals to attack your own tissues, which is called inflammation. It can punch holes in arteries to start forming plaques that can lead to heart attacks, it can damage the genetic material in cells to increase risk for cancers, and it can accelerate the loss of nerves to cause debilitating muscle weakness. An overactive immune system can cause muscle cells to break down through loss of energy-producing mitochondria and increased cell death (Clin Calcium, 2017;27(1):45-52; Int J Mol Sci, Apr 12, 2010;11(4):1509-26).

If inflammation is a major cause of muscle loss, treatment should include exercise, which decreases inflammation by dampening down your immune system. Competitive masters athletes 40-80 years old, who train 4-5 times a week, lose far less muscle size or strength than their non-exercising peers (The Physician and Sportsmedicine, October 2011;39(3):172-8). Eighty-year-old men who still compete in sports have been found to have more muscle fibers than inactive younger men (Journal of Applied Physiology, March 24, 2016). At this time the most effective way to decrease the rate at which you lose muscle size and function is to exercise regularly.

How Exercise Reduces Inflammation
To make a muscle stronger, you have to exercise that muscle vigorously enough to feel burning in the muscle and damage muscle fibers. Then, when the muscle heals, it is bigger and stronger. Theoretically, damage to any cells in your body turns on your immune system and therefore can cause inflammation, but most studies show that in the long run, exercise helps to prevent or reduce inflammation. Exercise increases cell damage, and the greater the intensity, the greater the damage. Initially, exercise turns on your immune system, but your body quickly responds by producing large amounts of antioxidants and anti-inflammatory hormones to dampen down your immunity (Brain, Behavior, and Immunity, March 2017;61:60-68). Long after you finish exercising, your body still has anti-inflammatory hormones that help to protect you against future cell damage and infections (BMC Sports Science, Medicine and Rehabilitation, Jan 6, 2022;14(5)).

A major source of inflammation is a high rise in blood sugar that causes sugar to stick to the membranes of cells and damage them. Exercise helps to control rises in blood sugar after meals and therefore helps to prevent inflammation. Your blood sugar rises after eating, and to prevent blood sugar from rising too high, your pancreas releases insulin which lowers blood sugar by driving sugar into your muscles and liver, the only places that store significant amounts of sugar in your body. When your muscles and liver are full of sugar, all extra sugar is converted to triglycerides that, in high levels, can cause inflammation. Exercising specifically increases insulin sensitivity (Curr Cardiol Rep, Dec 2016;18(12):117) that rapidly lowers blood sugar by driving sugar from your bloodstream into your muscles and liver to prevent high rises in blood sugar and triglycerides.

My Recommendations
I believe that every healthy person should have a progressive resistance program as part of their regular exercise program. It can help to stave off disability and disease. If you have never lifted weights before, you should first check with your doctor for any potential problems and in the beginning, seek out instructions on progressive resistance training. See Weight Training for Middle-Aged and Older People
Resistance Exercise You Can Do at Home

Caution: Check with your doctor before starting a new exercise program or changing the intensity of your existing program.